Glycyrrhiza uralensis

Glycyrrhiza uralensis(Leguminosae family), an herb medicine, is distributed all over the world, especially in northwest and northeast of China. It is wildly used in traditional Chinese medicine with its dried roots and rhizomes for thousands of years. Ancient records in Shennong Materia Medica demonstrated that G. uralensis was good for relieving cough and reducing sputum, regulating of painful menstruation and toxin resolving. Modern pharmacological studies show that the active extract of G. uralensis have the function of anti-oxidant, anti-inflammatory, anti-tumor, anti-viral, liver protection, memory-enhancement, and so on. In addition to its pharmacological effects, G. uralensis is also wildly used in food processing as a natural non-caloric sweetener. With the research development, many chemical components of G. uralensis are gradually discovered, such as flavonoids, triterpenoid saponins, coumarin and polysaccharides, which give it multiple pharmaceutical function.

About GURFAP        

The platform includes co-expression network, gene families, KEGG pathways and analysis tools, such as blast, motif search and GSEA. We applied PCC algorithm to construct co-expression network through integration of 35 samples of RNA-seq data. We combined several analysis tools such as iTAK, blast, HMM, interProScan, Pfam to classify the proteins into different families: cytochrome P450 families, transcription regulators, kinase proteins, ubiquitin proteasome system, carbohydrate-active enzymes and EAR motif-containing proteins. In addition,GO terms were collected from AgriGOv2. Enzymes and metabolism pathways were annotated by KOALA from KEGG database.

In GURFAP, co-expression networks of genes can be browsed from gene families or metabolism pathways and functional annotation. Moreover, Blast, cis-element enrichment and Gene Sets analysis tools were provided to explore potential function of group genes.